Descripción
About this book
This book describes the evolution of ideas relating to the mechanism of muscular contraction since the discovery of sliding filaments in 1954. An amazing variety of experimental techniques have been employed to investigate the mechanism of muscular contraction and relaxation. Some background of these various techniques is presented in order to gain a fuller appreciation of their strengths and weaknesses. Controversies in the muscle field are discussed along with some missed opportunities and false trails.
The pathway to ATP and the high energy phosphate bond will be discussed, as well as the discovery of myosin, contraction coupling and the emergence of cell and molecular biology in the muscle field. Numerous figures from original papers are also included for readers to see the data that led to important conclusions.
Table of contents (10 chapters)
Front Matter
Setting the Stage: Myosin, Actin, Actomyosin and ATP
Birth of the Sliding Filament Model of Muscular Contraction: Proposal
Glory Days: Establishment of the Sliding Filament Model of Muscular Contraction in the 1950s and 1960s
Excitation-Contraction Coupling and the Role of Calcium in Contraction and Relaxation in the 1950s and 1960s
Mechanics and Energetics of Muscular Contraction: Before Sliding Filaments and into the Modern Era
1972 Cold Spring Harbor Symposia on Quantitative Biology: The Mechanism of Muscle Contraction—Problem Solved?
Endosarcomeric and Exosarcomeric Cytoskeleton: Emergence of Cell and Molecular Biology in the Muscle Field
Excitation-Contraction Coupling and Regulation of Contraction in Skeletal Muscle: The Modern Synthesis
Molecular Mechanism of Force Production: From the Difficult 1980s to the Supercharged 1990s and Beyond
Erratum to
Back Matter
Keywords
- Human physiology
- Muscle physiology
- Muscular contraction
- Myosin
- Sliding filaments
Authors and Affiliations
-
Dept of Physiology and Cell Biology, Ohio State University, Columbus, USA
Jack A. Rall
Product Details
Publisher: Springer New York, NY
Book Format: eBook, PDF
Payment methods:
If you visit us from Chile:
You can pay in Chilean Pesos (CLP) through Flow, or Webpay.
*If you have a balance in your Paypal account, you can pay through Paypal as well, but you must change the currency (in the product’s currency exchanger, to American Dollars or Euros).
If you visit us from abroad (any country in the world except Chile):
You can pay in American Dollars (USD), or Euros (EUR), through PayPal. For this you must change the currency (in the currency exchanger of the product, to American Dollars, or Euros, depending on the currency of your choice).
Medios de Pago:
Si nos visitas desde Chile:
Puedes pagar en Pesos Chilenos (CLP) mediante Flow, o Webpay.
*Si tienes saldo en tu cuenta Paypal, puedes pagar mediante Paypal también, pero debes cambiar la divisa (en el cambiador de divisas del producto, a Dólares Americanos, o Euros).
Si nos visitas desde el Extranjero (cualquier país del mundo a excepción de Chile):
Puedes pagar en Dólares Americanos (USD), o Euros (EUR), mediante Paypal. Para esto debes cambiar la divisa (en el cambiador de divisas del producto, a Dólares Americanos, o Euros, según la divisa de tu elección).
Valoraciones
No hay valoraciones aún.